Resistance to Dolutegravir in Treatment-experienced Patients in South Africa: A Retrospective Cohort Study.

ABSTRACT:

Background

Dolutegravir resistance has been reported more frequently in patients with prior treatment experience compared to those on dolutegravir in first-line antiretroviral therapy (ART). The widespread use of dolutegravir in resource-limited programmatic settings might facilitate the emergence of resistance. Data on the prevalence of dolutegravir resistance from programmatic settings in Africa are scarce.

Methods

This retrospective observational cohort study assessed dolutegravir resistance in routine care settings of the Western Cape provincial public healthcare sector program between February 2021 and June 2024. Treatment-experienced adults who developed virologic failure (two HIV-1 RNA ≥1000 copies/mL), who had received dolutegravir-based ART for >24 months, were elig

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7617472 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature