Essential tremor disrupts rhythmic brain networks during naturalistic movement.

ABSTRACT: Essential Tremor (ET) is a very common neurological disorder characterised by involuntary rhythmic movements attributable to pathological synchronization within corticothalamic circuits. Previous work has focused on tremor in isolation, overlooking broader disturbances to motor control during naturalistic movements such as reaching. We hypothesised that ET disrupts the sequential engagement of large-scale rhythmic brain networks, leading to both tremor and deficits in motor planning and execution. To test this, we performed whole-head neuroimaging during an upper-limb reaching task using high-density electroencephalography in ET patients and healthy controls, alongside optically pumped magnetoencephalography in a smaller cohort. Key motor regions-including the supplementary motor area, pre

SUBMITTER: West TO 

PROVIDER: S-EPMC7617547 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature