Distinct roles of spindle checkpoint proteins in meiosis.

ABSTRACT: Gametes are produced via meiosis, a specialized cell division associated with frequent errors that cause birth defects and infertility. Uniquely in meiosis I, homologous chromosomes segregate to opposite poles, usually requiring their linkage by chiasmata, the products of crossover recombination.¹ The spindle checkpoint delays cell-cycle progression until all chromosomes are properly attached to microtubules,² but the steps leading to the capture and alignment of chromosomes on the meiosis I spindle remain poorly understood. In budding yeast meiosis I, Mad2 and Mad3^BUBR1 are equally important for spindle checkpoint delay, but biorientation of homologs on the meiosis I spindle requires Mad2, but not Mad3^BUBR1.^3,4 H

SUBMITTER: Mukherjee A 

PROVIDER: S-EPMC7617576 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature