Severe disease during both primary and secondary dengue virus infections in pediatric populations.

ABSTRACT: Dengue is a global epidemic causing over 100 million cases annually. The clinical symptoms range from mild fever to severe hemorrhage and shock, including some fatalities. The current paradigm is that these severe dengue cases occur mostly during secondary infections due to antibody-dependent enhancement after infection with a different dengue virus serotype. India has the highest dengue burden worldwide, but little is known about disease severity and its association with primary and secondary dengue infections. To address this issue, we examined 619 children with febrile dengue-confirmed infection from three hospitals in different regions of India. We classified primary and secondary infections based on IgM:IgG ratios using a dengue-specific enzyme-linked immunosorbent assay according to

SUBMITTER: Aggarwal C 

PROVIDER: S-EPMC7617637 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature