Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity.

ABSTRACT: Long noncoding RNAs (lncRNAs) are increasingly appreciated for their important functions in mammalian cells. However, how their functional capacities are encoded in their sequences and manifested in their structures remains largely unknown. Some lncRNAs bind to and modulate the availability of RNA-binding proteins, but the structural principles that underlie this mode of regulation are unknown. The NORAD lncRNA is a known decoy for Pumilio proteins, which modulate the translation and stability of hundreds of messenger RNAs and, consequently, a regulator of genomic stability and aging. Here we probed the RNA structure and long-range RNA-RNA interactions formed by human NORAD inside cells under different stressful conditions. We discovered a highly modular structure consisting of well-define

SUBMITTER: Farberov S 

PROVIDER: S-EPMC7617650 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature