The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabiditis elegans.

ABSTRACT: Sleep is caused by the depolarization of sleep-active neurons, which secrete gamma-aminobutyric acid (GABA) and neuropeptides such as conserved RFamide (c-terminal Arg-Phe-NH₂ motif) neuropeptides to dictate when an organism falls asleep and when it wakes up.^{1,2,3,4,5,6,7,8,9,10} However, the mechanisms by which neurotransmission from sleep-active neurons induces sleep and determines the duration of sleep remain poorly understood. Sleep in Caenorhabditis elegans crucially requires the single sleep-active RIS neuron, which induces sleep via the release of FLP-11 RFamide neuro

SUBMITTER: Rossi L 

PROVIDER: S-EPMC7617803 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature