Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity.

ABSTRACT: Precision application of targeted therapies is urgently needed to improve long-term clinical outcomes for children affected by inflammatory arthritis, known as juvenile idiopathic arthritis (JIA). Progress has been hampered by our limited understanding of the cellular basis of inflammation in the target tissue of the disease, the synovial membrane. Here, we analyzed biopsies from the inflamed joints of treatment-naïve children with JIA, early in the course of their disease, using single-cell RNA sequencing, multiplexed immunofluorescence, and spatial transcriptomics to establish a cellular atlas of the JIA synovium. We identified distinct spatial tissue niches, composed of specific stromal and immune cell populations. In addition, we localized genes linked to arthritis severity and disease

SUBMITTER: Bolton C 

PROVIDER: S-EPMC7617933 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature