Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain.

ABSTRACT: Hippocampal ripples are highly synchronized neuronal population patterns reactivating past waking experiences in the offline brain. Whether the level, structure, and content of ripple-nested activity are consistent across consecutive events or are tuned in each event remains unclear. By profiling individual ripples using laminar currents in the mouse hippocampus during sleep/rest, we identified ripples in stratum pyramidale that feature current sinks in stratum radiatum (Rad^sink) versus stratum lacunosum-moleculare (LM^sink). These two ripple profiles recruit neurons differently. Rad^sink ripples integrate recent motifs of waking coactivity, combining superficial and deep CA1 principal cells into denser, higher-dimensional patterns that undergo hour-long stab

SUBMITTER: Castelli M 

PROVIDER: S-EPMC7618225 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature