JULIEs: nanostructured polytrodes for low traumatic extracellular recordings and stimulation in the mammalian brain.

ABSTRACT: Objective.Extracellular microelectrode techniques are the most widely used approach to interrogate neuronal populations. However, regardless of the manufacturing method used, damage to the vasculature and circuit function during probe insertion remains a concern. This issue can be mitigated by minimising the footprint of the probe used. Reducing the size of probes typically requires either a reduction in the number of channels present in the probe, or a reduction in the individual channel area. Both lead to less effective coupling between the probe and extracellular signals of interest.Approach.Here, we show that continuously drawn SiO₂-insulated ultra-microelectrode fibres offer an attractive substrate to address these challenges. Individual fibres can be fabricat

SUBMITTER: Racz RR 

PROVIDER: S-EPMC7618266 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature