An extended phase graph-based framework for DANTE-SPACE simulations including physiological, temporal, and spatial variations.

ABSTRACT:

Purpose

The delay alternating with nutation for tailored excitation (DANTE)-sampling perfection with application-optimized contrasts (SPACE) sequence facilitates 3D intracranial vessel wall imaging with simultaneous suppression of blood and CSF. However, the achieved image contrast depends closely on the selected sequence parameters, and the clinical use of the sequence is limited in vivo by observed signal variations in the vessel wall, CSF, and blood. This paper introduces a comprehensive DANTE-SPACE simulation framework, with the aim of providing a better understanding of the underlying contrast mechanisms and facilitating improved parameter selection and contrast optimization.

Methods

An extended phase graph formalism was developed for efficient spin ensemble simulation

SUBMITTER: de Buck MHS 

PROVIDER: S-EPMC7618303 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature