Sleep-wake-related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses.

ABSTRACT: Wakefulness and sleep affect the brain's ability to exhibit plastic changes.^1,2 For instance, the potentiation of cortical excitatory synaptic connections is associated with the active period, when animals are mainly awake.^3,4,5,6,7 It is unclear, however, how changes in neuronal physiology that are associated with sleep-wake history, affect the mechanisms responsible for synaptic plasticity. Recently, it has been shown that sleep-wake history alters transmembrane chloride (Cl^-) gradients in cortical pyramidal neurons via Cl^- cotransporter activity, which shifts the reversal potential for gamma-aminobutyric acid (GABA) type A receptors (E

SUBMITTER: Alfonsa H 

PROVIDER: S-EPMC7618421 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature