Polygenic prediction of coronary heart disease among 130 000 Mexican adults.

ABSTRACT:

Aims

Most polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from European ancestry populations. This paper evaluates the performance of CHD PRSs in a Mexican population.

Methods and results

133 207 participants aged 35-79 years from the Mexico City Prospective Study were included. Eight PRSs (comprising 44-6 472 620 polymorphisms) were selected for prediction of CHD (defined as self-reported prior heart attack or angina, or CHD death before age 80 years). Logistic regression was adjusted for age, sex, and the first seven genetic principal components, before and after adjustment for other cardiovascular risk factors. The area under the receiving operating characteristic curve ('C-statistic') was also estimated. Of the included participants, 67% were wo

SUBMITTER: Liu T 

PROVIDER: S-EPMC7618473 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature