Medication and atypical brain maturation in psychosis associated with long-term cognitive decline and symptom progression.

ABSTRACT:

Background

Clinical progression during psychosis has been closely associated with grey matter abnormalities resulting from atypical brain development. However, the complex interplay between psychopathology and heterogeneous maturational trajectories challenges the identification of neuroanatomical features that anticipate symptomatic decline.

Aims

To investigate cortical volume longitudinal deviations in first-episode psychosis (FEP) using normative modelling, exploring their relationship with long-term cognitive and symptomatic outcomes, as well as their cytoarchitectural and neurobiological underpinnings.

Method

We collected magnetic resonance imaging (MRI), cognitive and symptomatic data from 195 healthy controls and 357 drug-naïve or minimally medicated FEP indivi

SUBMITTER: Aleman-Morillo C 

PROVIDER: S-EPMC7618483 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature