DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38,123 UK Biobank participants.

ABSTRACT: Despite advancements in fracture prediction tools and osteoporosis management, hip fractures remain a significant consequence of bone fragility, with a 22% one-year mortality. Hip geometric measures (GMs) have been associated with fracture risk; however, their strong correlation hinders the identification of independent influences, leaving their relative predictive value unclear. Statistical shape modelling (SSM) provides a more holistic assessment of hip shape compared to using pre-determined GMs. This study aimed to evaluate whether SSM-derived hip shape from dual-energy X-ray absorptiometry (DXA) scans can predict hip fracture, independently of individual GMs. Previously, we applied SSM to left hip DXA images in UK Biobank, a large prospective cohort with linked hospital records, genera

SUBMITTER: Scott S 

PROVIDER: S-EPMC7618572 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature