Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions.

ABSTRACT: Six months of drug treatment is standard of care for drug-sensitive pulmonary tuberculosis (TB). Understanding the factors determining the length of treatment required for durable cure would allow individualization of treatment durations. We conducted a prospective, randomized, controlled noninferiority trial (PredictTB) of 4 versus 6 months of chemotherapy in patients with pulmonary TB in South Africa and China. Seven hundred and four participants with newly diagnosed, drug-sensitive TB were enrolled and stratified on the basis of radiographic disease characteristics assessed by FDG PET/CT imaging. Participants with less extensive disease (n = 273) were randomly assigned at week 16 to complete therapy after 4 months or continue receiving treatment for 6 months. This study was stopp

SUBMITTER: Malherbe ST 

PROVIDER: S-EPMC7618742 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature