Global genomic diversity of Pseudomonas aeruginosa in bronchiectasis.

ABSTRACT:

Objectives

Pseudomonas aeruginosa is the most common pathogen in the bronchiectasis lung, associated with worsened outcomes. P. aeruginosa genomic studies in this context have been limited to single-country, European studies. We aimed to determine strain diversity, adaptation mechanisms, and AMR features to better inform treatment.

Methods

P. aeruginosa from 180 bronchiectasis patients in 15 countries, obtained prior to a phase 3, randomised clinical trial (ORBIT-3), were analysed by whole-genome sequencing. Phylogenetic groups and sequence types were determined, and between versus within patient genetic diversity compared using Analysis of Molecular Variance (AMOVA). The frequency of AMR-associated genes and mutations was also determined.

Results

A total of 2854 P. a

SUBMITTER: Harrington NE 

PROVIDER: S-EPMC7618805 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature