Non-invasive predictors of prognosis of Asian patients with histopathologically-confirmed lean nonalcoholic fatty liver disease.

ABSTRACT:

Background

The prognostic factors of morbidity and mortality in patients with lean NAFLD (body mass index < 25.0 kg/m²) are unknown.

Methods

In this retrospective study, 446 Japanese patients with histopathologically-confirmed NAFLD (lean NAFLD, n = 170) were followed for liver events, cardiovascular events, type 2 diabetes mellitus, and non-liver malignancies. The median observation period was 4.6 years. We also investigated the predictors of severe fibrosis (stage 3-4) and mortality in lean NAFLD patients.

Results

Glycolipid metabolic markers, liver function tests, NAFLD fibrosis score (NFS), and histological scoring were significantly lower in lean NAFLD patients than in non-lean NAFLD. The incidence of liver cancer was higher while that of T2DM was lowe

SUBMITTER: Iritani S 

PROVIDER: S-EPMC7640447 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature