SAlign-a structure aware method for global PPI network alignment.

ABSTRACT:

Background

High throughput experiments have generated a significantly large amount of protein interaction data, which is being used to study protein networks. Studying complete protein networks can reveal more insight about healthy/disease states than studying proteins in isolation. Similarly, a comparative study of protein-protein interaction (PPI) networks of different species reveals important insights which may help in disease analysis and drug design. The study of PPI network alignment can also helps in understanding the different biological systems of different species. It can also be used in transfer of knowledge across different species. Different aligners have been introduced in the last decade but developing an accurate and scalable global alignment algorithm that can ens

SUBMITTER: Ayub U 

PROVIDER: S-EPMC7640460 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature