Cancer associated macrophage-like cells and prognosis of esophageal cancer after chemoradiation therapy.

ABSTRACT:

Background

Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with poorer progression free survival (PFS) and overall survival (OS) in a variety of cancers; however, no study has evaluated their clinical significance in esophageal cancer (EC).

Methods

To examine this significance, we ran a 2 year prospective pilot study consisting of newly diagnosed stage I-III EC patients (n = 32) receiving chemoradiotherapy (CRT). CAML sizes were sequentially monitored prior to CRT (BL), ~ 2 weeks into treatment (T1), and at the first available sample after the completion of CRT (T2).

Results

We found CAMLs in 88% (n = 28/32) of all

SUBMITTER: Gironda DJ 

PROVIDER: S-EPMC7640696 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature