Anterior segment alterations in congenital primary aphakia-a clinicopathologic report of five cases.

ABSTRACT:

Purpose

To report the clinicopathological features of corneal buttons in patients with congenital primary aphakia.

Methods

Five corneal specimens of five patients with congenital primary aphakia who underwent penetrating keratoplasty (PKP) were studied by light microscopy, and immunohistochemistry with anti-smooth muscle (SMA) antibody.

Results

All patients were born from consanguineous parents. Of the five, two patients were identical twins. All eyes were microphthalmic. In four patients, congenital primary aphakia was bilateral and in one patient (Patient 3), it was unilateral. PKP failed in all eyes due to hypotony. Histologically, Bowman's layer was absent in all specimens. The corneal stroma was thin; however, the stromal collagen showed thick and irregularly arr

SUBMITTER: Chaurasia S 

PROVIDER: S-EPMC7640842 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature