Ontology highlight
ABSTRACT:
SUBMITTER: Peng J
PROVIDER: S-EPMC7640934 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Peng Junxuan J Cai Zuchao Z Zhao Ruixue R Chen Jiahao J Liu Guochao G Dong Chao C Lim David D Feng Zhihui Z
Toxicology research 20200831 5
This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tiss ...[more]