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The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs.


ABSTRACT: This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

SUBMITTER: Peng J 

PROVIDER: S-EPMC7640934 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs.

Peng Junxuan J   Cai Zuchao Z   Zhao Ruixue R   Chen Jiahao J   Liu Guochao G   Dong Chao C   Lim David D   Feng Zhihui Z  

Toxicology research 20200831 5


This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tiss  ...[more]

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