Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
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ABSTRACT:
SUBMITTER: LaFave LM
PROVIDER: S-EPMC7641015 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
LaFave Lindsay M LM Kartha Vinay K VK Ma Sai S Meli Kevin K Del Priore Isabella I Lareau Caleb C Naranjo Santiago S Westcott Peter M K PMK Duarte Fabiana M FM Sankar Venkat V Chiang Zachary Z Brack Alison A Law Travis T Hauck Haley H Okimoto Annalisa A Regev Aviv A Buenrostro Jason D JD Jacks Tyler T
Cancer cell 20200723 2
Regulatory networks that maintain functional, differentiated cell states are often dysregulated in tumor development. Here, we use single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma (LUAD). We identify an epigenomic continuum representing loss of cellular identity and progression toward a metastatic state. We define co-accessible regulatory programs and infer key activating and repressive chromatin regulators of these cell states. Among these c ...[more]
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