Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development.

ABSTRACT: Recent studies have revealed non-canonical activities of apoptotic caspases involving specific modulation of gene expression, such as limiting asymmetric divisions of stem-like cell types. Here we report that CED-3 caspase negatively regulates an epidermal p38 stress-responsive MAPK pathway to promote larval development in C. elegans. We show that PMK-1 (p38 MAPK) primes animals for encounters with hostile environments at the expense of retarding post-embryonic development. CED-3 counters this function by directly cleaving PMK-1 to promote development. Moreover, we found that CED-3 and PMK-1 oppose each other to balance developmental and stress-responsive gene expression programs. Specifically, expression of more than 300 genes is inversely regulated by CED-3 and PMK-1. Analyses of these g

SUBMITTER: Weaver BP 

PROVIDER: S-EPMC7641037 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature