Distinct macrophage populations and phenotypes associated with IL-4 mediated immunomodulation at the host implant interface.

ABSTRACT: The host macrophage response to implants has shown to be affected by tissue location and physio-pathological conditions of the patient. Success in immunomodulatory strategies is thus predicated on the proper understanding of the macrophage populations participating on each one of these contexts. The present study uses an in vivo implantation model to analyze how immunomodulation via an IL-4 eluting implant affects distinct macrophage populations at the tissue-implant interface and how this may affect downstream regenerative processes. Populations identified as F4/80⁺, CD68⁺ and CD11b⁺ macrophages at the peri-implant space showed distinct susceptibility to polarize towards an M2-like phenotype under the effects of delivered IL-4. Also, the presence of the co

SUBMITTER: Hachim D 

PROVIDER: S-EPMC7641101 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature