The transition from primary colorectal cancer to isolated peritoneal malignancy is associated with an increased tumour mutational burden.

ABSTRACT: Colorectal Peritoneal metastases (CPM) develop in 15% of colorectal cancers. Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS & HIPEC) is the current standard of care in selected patients with limited resectable CPM. Despite selection using known prognostic factors survival is varied and morbidity and mortality are relatively high. There is a need to improve patient selection and a paucity of research concerning the biology of isolated CPM. We aimed to determine the biology associated with transition from primary CRC to CPM and of patients with CPM not responding to treatment with CRS & HIPEC, to identify those suitable for treatment with CRS & HIPEC and to identify targets for existing repurposed or novel treatment strategies. A cohort of patients with CPM treated with C

SUBMITTER: Hallam S 

PROVIDER: S-EPMC7641117 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature