Effect of the similarity of gut microbiota composition between donor and recipient on graft function after living donor kidney transplantation.

ABSTRACT: Graft outcomes of unrelated donor kidney transplant are comparable with those of related donor kidney transplant despite their genetic distance. This study aimed to identify whether the similarity of donor-recipient gut microbiota composition affects early transplant outcomes. Stool samples from 67 pairs of kidney transplant recipients and donors were collected. Gut microbiota differences between donors and recipients were determined using weighted UniFrac distance. Among the donor-recipient pairs, 30 (44.8%) pairs were related, while 37 (55.2%) were unrelated. The unrelated pairs, especially spousal pairs, had similar microbial composition, and they more frequently shared their meals than related pairs did. The weighted UniFrac distance showed an inverse correlation with the 6-month allog

SUBMITTER: Kim JE 

PROVIDER: S-EPMC7641223 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature