Clinical impact and cost-effectiveness of integrating smoking cessation into lung cancer screening: a microsimulation model.

ABSTRACT:

Background

Low-dose computed tomography (CT) screening can reduce lung cancer mortality in people at high risk; adding a smoking cessation intervention to screening could further improve screening program outcomes. This study aimed to assess the impact of adding a smoking cessation intervention to lung cancer screening on clinical outcomes, costs and cost-effectiveness.

Methods

Using the OncoSim-Lung mathematical microsimulation model, we compared the projected lifetime impact of a smoking cessation intervention (nicotine replacement therapy, varenicline and 12 wk of counselling) in the context of annual low-dose CT screening for lung cancer in people at high risk to lung cancer screening without a cessation intervention in Canada. The simulated population consisted of Canad

SUBMITTER: Evans WK 

PROVIDER: S-EPMC7641238 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature