Therapeutic Applications of Cannabinoids in Cardiomyopathy and Heart Failure.

ABSTRACT: A large number of cannabinoids have been discovered that could play a role in mitigating cardiac affections. However, none of them has been as widely studied as cannabidiol (CBD), most likely because, individually, the others offer only partial effects or can activate potential harmful pathways. In this regard, CBD has proven to be of great value as a cardioprotective agent since it is a potent antioxidant and anti-inflammatory molecule. Thus, we conducted a review to condensate the currently available knowledge on CBD as a therapy for different experimental models of cardiomyopathies and heart failure to detect the molecular pathways involved in cardiac protection. CBD therapy can greatly limit the production of oxygen/nitrogen reactive species, thereby limiting cellular damage, protectin

SUBMITTER: Garza-Cervantes JA 

PROVIDER: S-EPMC7641267 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature