Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids.

ABSTRACT: The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the self-produced extracellular biofilm matrix confer high resistance to antibiotics, triggering infections difficult to treat. Therefore, novel antibiofilm strategies targeting matrix components are urgently needed. The Biofilm Associated Protein, Bap, expressed by staphylococcal species adopts functional amyloid-like structures as scaffolds of the biofilm matrix. In this work we have focused on identifying agents targeting Bap-related amyloid-like aggregates as a strategy to combat S. aureus biofilm-related infections. We identified that the flavonoids, quercetin, myricetin

SUBMITTER: Matilla-Cuenca L 

PROVIDER: S-EPMC7641273 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature