Treatment of Progressive Multifocal Leukoencephalopathy Using Immune Restoration.

ABSTRACT: Progressive multifocal leukoencephalopathy (PML) is a viral disease of the brain associated with immunodeficiency, immune suppressing medications, and malignancy. In the absence of effective anti-viral therapy for the causative JC virus, immune restoration has emerged as the critical therapeutic alternative. The evolving treatment of PML (and other rare JC virus-associated neurologic syndromes) requires consideration of baseline immune functioning and comorbid diseases while selecting from a number of therapeutic options to restore an effective immune response. This review focuses on the current options for management of PML in typical situations where this disease presents, including several where immune restoration is a standard therapeutic approach such as in PML associated with HIV/AID

SUBMITTER: Dunham SR 

PROVIDER: S-EPMC7641288 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature