Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects.

ABSTRACT: To describe the clinical syndrome of 4 new patients with seizure-related 6 homolog like 2 antibodies (SEZ6L2-abs), study the antibody characteristics, and evaluate their effects on neuronal cultures. SEZ6L2-abs were initially identified in serum and CSF of a patient with cerebellar ataxia by immunohistochemistry on rat brain sections and immunoprecipitation from rat cerebellar neurons. We used a cell-based assay (CBA) of HEK293 cells transfected with SEZ6L2 to test the serum of 95 patients with unclassified neuropil antibodies, 331 with different neurologic disorders, and 10 healthy subjects. Additional studies included characterization of immunoglobulin G (IgG) subclasses and the effects of SEZ6L2-abs on cultures of rat hippocampal neurons. In addition to the index patient, SEZ6L2-abs wer

SUBMITTER: Landa J 

PROVIDER: S-EPMC7641326 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature