The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites.

ABSTRACT: Diplomonad parasites of the genus Giardia have adapted to colonizing different hosts, most notably the intestinal tract of mammals. The human-pathogenic Giardia species, Giardia intestinalis, has been extensively studied at the genome and gene expression level, but no such information is available for other Giardia species. Comparative data would be particularly valuable for Giardia muris, which colonizes mice and is commonly used as a prototypic in vivo model for investigating host responses to intestinal parasitic infection. Here we report the draft-genome of G. muris. We discovered a highly streamlined genome, amongst the most densely encoded ever described for a nuclear eukaryotic genome. G. muris and G. intestinalis share

SUBMITTER: Xu F 

PROVIDER: S-EPMC7641422 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature