Evidences of histologic thrombotic microangiopathy and the impact in renal outcomes of patients with IgA nephropathy.

ABSTRACT:

Introduction

IgA nephropathy (IgAN) is the most common primary glomerulopathy worldwide. According to the Oxford Classification, changes in the kidney vascular compartment are not related with worse outcomes. This paper aims to assess the impact of thrombotic microangiopathy (TMA) in the outcomes of Brazilian patients with IgAN.

Materials and methods

Analysis of clinical data and kidney biopsy findings from patients with IgAN to assess the impact of TMA on renal outcomes.

Results

The majority of the 118 patients included were females (54.3%); mean age of 33 years (25;43); hypertension and hematuria were observed in 67.8% and 89.8%, respectively. Median creatinine: 1.45mg/dL; eGFR: 48.8ml/min/1.73m2; 24-hour proteinuria: 2.01g; low serum C3: 12.5%. Regarding to Oxford

SUBMITTER: Neves PDMM 

PROVIDER: S-EPMC7641451 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature