Systematic review of pre-clinical therapies for post-operative atrial fibrillation.

ABSTRACT:

Background

Post-operative atrial fibrillation (POAF) is a frequent cardiothoracic surgery complication that increases hospital stay, mortality and costs. Despite decades of research, there has been no systematic overview and meta-analysis of preclinical therapies for POAF in animal models.

Methods

We performed a systematic search of MEDLINE and EMBASE from their inception through September 2020 to determine the effect of preclinical POAF therapies on primary efficacy outcomes using a prospectively registered protocol (CRD42019155649). Bias was assessed using the SYRCLE tool and CAMARADES checklist.

Results

Within the 26 studies that fulfilled our inclusion criteria, we identified 4 prevention strategies including biological (n = 5), dietary (n = 2), substrate modifica

SUBMITTER: Seo C 

PROVIDER: S-EPMC7641461 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature