Antibiotics for Aspiration Pneumonia in Neurologically Impaired Children.

ABSTRACT:

Objective

To compare hospital outcomes associated with commonly used antibiotic therapies for aspiration pneumonia in children with neurologic impairment (NI).

Design/methods

A retrospective study of children with NI hospitalized with aspiration pneumonia at 39 children's hospitals in the Pediatric Health Information System database. Exposure was empiric antibiotic therapy classified by antimicrobial activity. Outcomes included acute respiratory failure, intensive care unit (ICU) transfer, and hospital length of stay (LOS). Multivariable regression evaluated associations between exposure and outcomes and adjusted for confounders, including medical complexity and acute illness severity.

Results

In the adjusted analysis, children receiving Gram-negative coverage alone h

SUBMITTER: Thomson J 

PROVIDER: S-EPMC7641495 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature