Anatomical Variation in Mesenteric Macrophage Phenotypes in Crohn's Disease.

ABSTRACT:

Introduction

Clinical trials are currently investigating whether an extended mesenteric resection for ileocecal resections could reduce postoperative recurrence in Crohn's disease. Resection of the mesorectum, which contains proinflammatory macrophages, during proct(ocol)ectomy, is associated with reduced recurrent inflammation and improved wound healing. We aimed to characterize the macrophages in the ileocecal mesentery, which were compared with those in the mesorectum, to provide a biological rationale for the ongoing trials.

Methods

In 13 patients with Crohn's disease and 4 control patients undergoing a proctectomy, tissue specimens were sampled at 3 locations from the mesorectum: distal (rectum), middle, and proximal (sigmoid). In 38 patients with Crohn's disease and 7

SUBMITTER: van der Meer JHM 

PROVIDER: S-EPMC7641506 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature