Acute-on-chronic liver failure as a major predictive factor for mortality in patients with variceal bleeding.

ABSTRACT:

Background/aims

This study examined the risk factors associated with mortality in cirrhotic patients hospitalized with variceal bleeding, and evaluated the effects of acute-on-chronic liver failure (ACLF) on the prognosis of these patients.

Methods

This study was retrospectively conducted on patients registered in the Korean acute-on-chronic liver failure study cohort, and on 474 consecutive cirrhotic patients hospitalized with variceal bleeding from January 2013 to December 2013 at 21 university hospitals. ACLF was defined as described by the European Association for the Study of Liver-Chronic Liver Failure Consortium.

Results

Among a total of 474 patients, 61 patients were diagnosed with ACLF. The cumulative overall survival (OS) rate was lower in the patients with

SUBMITTER: Shin J 

PROVIDER: S-EPMC7641565 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature