Precision medicine in nonalcoholic fatty liver disease: New therapeutic insights from genetics and systems biology.

ABSTRACT: Despite more than two decades of extensive research focusing on nonalcoholic fatty liver disease (NAFLD), no approved therapy for steatohepatitis-the severe histological form of the disease-presently exists. More importantly, new drugs and small molecules with diverse molecular targets on the pathways of hepatocyte injury, inflammation, and fibrosis cannot achieve the primary efficacy endpoints. Precision medicine can potentially overcome this issue, as it is founded on extensive knowledge of the druggable genome/proteome. Hence, this review summarizes significant trends and developments in precision medicine with a particular focus on new potential therapeutic discoveries modeled via systems biology approaches. In addition, we computed and simulated the potential utility of the NAFLD poly

SUBMITTER: Sookoian S 

PROVIDER: S-EPMC7641575 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature