MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells.

ABSTRACT: The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood. Using an innovated, ultra-sensitive technique, we address here enigmatic features underlying the communications between MYC and its enhancers in relation to the transcriptional process. MYC thus interacts with its flanking enhancers in a mutually exclusive manner documenting that enhancer hubs impinging on MYC detected in large cell populations likely do not exist in single cells. Dynamic encounters with pathologically activated enhancers responsive to a range of environmental cues, involved <10% of active MYC alleles at any given time in colon cancer cells. Being the most central node of the chromatin network, MYC itself likely drives its communications with flanking enhancer

SUBMITTER: Sumida N 

PROVIDER: S-EPMC7641766 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature