Proteomics identifies differences in fibrotic potential of extracellular vesicles from human tendon and muscle fibroblasts.

ABSTRACT:

Background

Fibroblasts are the powerhouses responsible for the production and assembly of extracellular matrix (ECM). Their activity needs to be tightly controlled especially within the musculoskeletal system, where changes to ECM composition affect force transmission and mechanical loading that are required for effective movement of the body. Extracellular vesicles (EVs) are a mode of cell-cell communication within and between tissues, which has been largely characterised in cancer. However, it is unclear what the role of healthy fibroblast-derived EVs is during tissue homeostasis.

Methods

Here, we performed proteomic analysis of small EVs derived from primary human muscle and tendon cells to identify the potential functions of healthy fibroblast-derived EVs.

Results

SUBMITTER: Yeung CC 

PROVIDER: S-EPMC7641822 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature