Depression and cardiovascular risk-association among Beck Depression Inventory, PCSK9 levels and insulin resistance.

ABSTRACT:

Background

Depression and cardiovascular disease (CVD) are among the most common causes of disability in high-income countries, depression being associated with a 30% increased risk of future CV events. Depression is twice as common in people with diabetes and is associated with a 60% rise in the incidence of type 2 diabetes, an independent CVD risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of low-density lipoprotein cholesterol, has been related to a large number of CV risk factors, including insulin resistance. Aim of this study was to investigate whether the presence of depression could affect PCSK9 levels in a population of obese subjects susceptible to depressive symptoms and how these changes may mediate a pre-diabetic risk.

Results

SUBMITTER: Macchi C 

PROVIDER: S-EPMC7641831 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature