A tumour suppressive relationship between mineralocorticoid and retinoic acid receptors activates a transcriptional program consistent with a reverse Warburg effect in breast cancer.

ABSTRACT:

Background

The role of nuclear receptors in both the aetiology and treatment of breast cancer is exemplified by the use of the oestrogen receptor (ER) as a prognostic marker and treatment target. Treatments targeting the oestrogen signalling pathway are initially highly effective for most patients. However, for the breast cancers that fail to respond, or become resistant, to current endocrine treatments, the long-term outlook is poor. ER is a member of the nuclear receptor superfamily, comprising 48 members in the human, many of which are expressed in the breast and could be used as alternative targets in cases where current treatments are ineffective.

Methods

We used sparse canonical correlation analysis to interrogate potential novel nuclear receptor expression relationshi

SUBMITTER: Doan TB 

PROVIDER: S-EPMC7641839 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature