MiR-206 as a prognostic and sensitivity biomarker for platinum chemotherapy in epithelial ovarian cancer.

ABSTRACT:

Background

Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to evaluate the prognostic and platinum-resistance predictive value of miR-206 in EOC patients and to investigate the functional roles of miR-206 in regulating the platinum resistance of EOC and the underlying mechanism.

Methods

MiRNA expression profiling in EOC specimens was performed using a TaqMan miRNA array. miR-206 expression was confirmed by quantitative real-time PCR (qRT-PCR) analysis. Overexpression of miR-206 in EOC cell lines was achieved by the stable

SUBMITTER: Yu X 

PROVIDER: S-EPMC7641844 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature