Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research.

ABSTRACT: Epidemiologists have for many decades reported on the patterns and distributions of diabetes within and between populations and have helped to elucidate the aetiology of the disease. This has helped raise awareness of the tremendous burden the disease places on individuals and societies; it has also identified key risk factors that have become the focus of diabetes prevention trials and helped shape public health recommendations. Recent developments in affordable high-throughput genetic and molecular phenotyping technologies have driven the emergence of a new type of epidemiology with a more mechanistic focus than ever before. Studies employing these technologies have identified gene variants or causal loci, and linked these to other omics data that help define the molecular processes medi

SUBMITTER: Franks PW 

PROVIDER: S-EPMC7641957 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature