Laryngotracheal Mucosal Surface Expression of Candidate Biomarkers in Idiopathic Subglottic Stenosis.

ABSTRACT:

Objectives

Idiopathic subglottic stenosis (iSGS) is an inflammatory process leading to fibrosis and narrowing of the laryngotracheal airway. There is variability in patient response to surgical intervention, but the mechanisms underlying this variability are unknown. In this pilot study, we measure expression of candidate targets at the mucosal surface of the subglottis in iSGS patients. We aim to identify putative biomarkers for iSGS that provide insights into the molecular basis of disease progression, yield a gene signature for the disease, and/or predict a response to therapy.

Study design

In vitro comparative study of human cells.

Methods

Levels of candidate transcripts and proteins were measured in healthy and stenotic laryngotracheal tissue specimens taken from

SUBMITTER: Liu MM 

PROVIDER: S-EPMC7641987 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature