Association of Known Melanoma Risk Factors with Primary Melanoma of the Scalp and Neck.

ABSTRACT:

Background

Scalp and neck (SN) melanoma confers a worse prognosis than melanoma of other sites but little is known about its determinants. We aimed to identify associations between SN melanoma and known risk genes, phenotypic traits, and sun exposure patterns.

Methods

Participants were cases from the Western Australian Melanoma Health Study (n = 1,200) and the Genes, Environment, and Melanoma Study (n = 3,280). Associations between risk factors and SN melanoma, compared with truncal and arm/leg melanoma, were investigated using binomial logistic regression. Facial melanoma was also compared with the trunk and extremities, to evaluate whether associations were subregion specific, or reflective of the whole head/neck region.

Results

Compared with other sit

SUBMITTER: Wood RP 

PROVIDER: S-EPMC7641988 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature