Associations of GlycA and high-sensitivity C-reactive protein with measures of lipolysis in adults with obesity.

ABSTRACT:

Background

Obesity-associated inflammation promotes metabolic dysfunction. However, it is unclear how different inflammatory biomarkers predict dysregulation in specific tissues/organs, particularly adipose tissue.

Objective

The aim of our study was to examine whether GlycA, a nuclear magnetic resonance-measured biomarker of inflammation, is a better predictor of insulin-suppressible lipolysis and other measures of metabolic dysfunction compared with high-sensitivity C-reactive protein (hsCRP) in human obesity.

Methods

This was a cross-sectional study of 58 nondiabetic adults with obesity (body mass index: 39.8 ± 7.0 kg/m², age 46.5 ± 12.2 years, 67.2% female) who underwent a frequently sampled intravenous glucose tolerance test in the fasted state. Noninsu

SUBMITTER: Levine JA 

PROVIDER: S-EPMC7642018 | biostudies-literature | 2020 Sep - Oct

REPOSITORIES: biostudies-literature