Association of Body Mass Index with Fecal Microbial Diversity and Metabolites in the Northern Finland Birth Cohort.

ABSTRACT:

Background

Obesity is an established risk factor for multiple cancer types. Lower microbial richness has been linked to obesity, but human studies are inconsistent, and associations of early-life body mass index (BMI) with the fecal microbiome and metabolome are unknown.

Methods

We characterized the fecal microbiome (n = 563) and metabolome (n = 340) in the Northern Finland Birth Cohort 1966 using 16S rRNA gene sequencing and untargeted metabolomics. We estimated associations of adult BMI and BMI history with microbial features and metabolites using linear regression and Spearman correlations (r_s ) and computed correlations between bacterial sequence variants and metabolites overall and by BMI category.

Results

Microbial richness, inclu

SUBMITTER: Loftfield E 

PROVIDER: S-EPMC7642019 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature