Genome-wide association study identifies candidate markers related to lincRNAs associated with male infertility in the Greek population.

ABSTRACT:

Background

Male infertility is currently one of the most common problems faced by couples worldwide. We performed a GWAS on Greek population and gathered statistically significant SNPs in order to investigate whether they lie within or near lncRNA regions.

Objectives

The aim of this study was to investigate whether polymorphisms on or near lncRNAs affect interactions with miRNAs and can cause male infertility.

Materials and methods

In the present study, a GWAS was conducted, using samples from 159 individuals (83 normozoospermic individuals and 76 patients of known fertility issues). Standard procedures for quality controls and association testing were followed, based on case-control testing.

Results

We detected six lncRNAs (LINC02231, LINC00347, LINC02134, NCR

SUBMITTER: Kyrgiafini MA 

PROVIDER: S-EPMC7642051 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature