Association study between single-nucleotide variants rs12097821, rs2477686, and rs10842262 and idiopathic male infertility risk in Serbian population with meta-analysis.

ABSTRACT:

Purpose

A genome-wide association study conducted in the Han Chinese population identified three single nucleotide variants rs12097821, rs2477686, and rs10842262 as being significantly associated with non-obstructive azoospermia. Our aim was to evaluate the possible association between these susceptibility loci and idiopathic male infertility risk in the Serbian population.

Methods

A case-control study was conducted on 431 male individuals from the Serbian population divided into two groups. The case group consisted of 208 males diagnosed with oligoasthenozoospermia or non-obstructive azoospermia, while the control group involved 223 fertile men who have fathered at least one child.

Results

According to codominant (P_codom = 0.048, OR_codom = 0.57,

SUBMITTER: Nemanja V 

PROVIDER: S-EPMC7642064 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature